To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. We are delighted by the commitment to gantenerumab as a potential new therapy for Alzheimer's disease, and the sustained clinical development of this antibody in this area of immense unmet medical . Arguing the life course approach is the best and simplest model for tracking mental development, Lawrence J. Whalley unlocks the mysteries of brain functionality, illuminating the processes that affect the brain during aging, the causes ... NursePartners, Inc. clinicians are participating in the administration of gantenerumab and the placebo. For more information about this trial or the study sites, please contact Hoffman-LaRoche at 888-662-6728 (U.S. only) or global.rochegenetechtrials@roche.com. Kaohsiung Medical University Hospital; Neurology, Chang Gung Memorial Foundation - Kaohsiung - Neurology, China Medical University Hospital; Neurology, National Taiwan University Hospital; Neurology, Taipei Veterans General Hospital-Neurology, Chang Gung Memorial Foundation - Linkou - Neurology. Two investigational treatments, solanezumab and gantenerumab, failed to prevent memory loss or cognitive decline in patients with a rare, inherited form of early-onset Alzheimer's disease, who were enrolled in a Phase 2/3 clinical trial (NCT01760005). ICH GCP. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading ... Aducanumab (BIIB037), an anti-amyloid beta monoclonal ... Federal Government Programs. Part 2 is an open-label extension (OLE). The healthy volunteer trial was posted on clinicaltrials.gov earlier this year, and started dosing in the third quarter, but Roche has only now said that the compound involved, coded RO7126209 or RG6102, is brain shuttle gantenerumab. Clinical trials of new drugs for Alzheimer disease ... The trial size will be increased from 360 to 770 participants, and a favorable outcome to the trial could be used by Roche to support a marketing application for gantenerumab. Roche Holding AG will set a reasonable price for its experimental Alzheimer's treatment gantenerumab should the drug show an . 2019 Dec 12;11(1):101. doi: 10.1186/s13195-019-0559-z. Amyloid Diseases Talk with your doctor and family members or friends about deciding to join a study. Gantenerumab Continues to Show Promise in Reduction of Amyloid Plaques. This book provides a compendium relating most of the principles of reliable RTCs to specific neurological diseases. Molecular Pathology of Alzheimer's Disease The primary endpoint for both trials is the assessment of signs and symptoms of dementia, measured as the clinical dementia rating-sum of boxes (CDR-SOB) score, determined as the change of the status from baseline to week 104. A positron emission tomography (PET) imaging substudy will be conducted within the main study. School of Medicine Center for Clinical Research, Kalamazoo, Michigan, United States, 49008, Saint Louis, Missouri, United States, 63132, Manchester, New Jersey, United States, 08759, Toms River, New Jersey, United States, 08775, Orangeburg, New York, United States, 10962, Staten Island, New York, United States, 10312, Matthews, North Carolina, United States, 28105, Raleigh, North Carolina, United States, 27609, Abington, Pennsylvania, United States, 19001, Plains, Pennsylvania, United States, 18705, Rhode Island Mood & Memory Research Institute, East Providence, Rhode Island, United States, 02914, University of Utah, Center for Alzheimer's Care Imaging & Research, Salt Lake City, Utah, United States, 84108, Ciudad Autonoma de Bs As, Argentina, 1426, Royal Adelaide Hospital; Memory Trials Centre, Adelaide, South Australia, Australia, 5000, Woodville, South Australia, Australia, 5011, Heidelberg Repatriation Hospital; Medical and Cognitive Research Centre, Heidelberg West, Victoria, Australia, 3081, Australian Alzheimer's Research Foundation, Nedlands, Western Australia, Australia, 6009, Shat Np Sveti Naum; 3Rd Clinic of Neurology, MBAL St. Marina; First Neurology Department, University of Calgary; Heritage Medical Research Clinic, Kawartha Centre - Redefining Healthy Aging, Jewish General Hospital / McGill University, Centre Hospitalier Affilie Universitaire de Quebec - Hopital de L'Enfant Jesus, McGill Univeristy; Douglas Mental Health University Institute; Neurological and Psychiatric, Aarhus Universitetshospital, Neurologisk Afdeling F, Demensklinikken, Hopital Pierre Wertheimer; Laboratoire De Neuro Psychologie, CHU de Limoges Hopital Dupuytren; Service de Medecine Geriatrique, CHU de la Timone - Hopital d Adultes; Service de Neurologie, CHU Rennes - hopital Hotel Dieu; Consultation Memoire - Gerontologie, Hopital Hautepierre; Centre dInvestigation Clinique, Hopital la Grave; Gerontopole - Centre de Recherche Clinique, ECRC Experimental and Clinical Research Center, Charité Campus Berlin Buch, Memory Clinic, PANAKEIA - Arzneimittelforschung Leipzig GmbH, Klinikum rechts der Isar der TU München; Klinikapotheke, Universitätsklinikum Ulm; Klinik für Neurologie, Studienzentrum Nordwest, Dr. med. Genentech's Gantenerumab Receives the US FDA's ... Y et, the presence of protective . This chapter reviews significant recent clinical trials involving potential disease-modifying drugs, including active immunotherapy, passive immunotherapy, γ-secretase inhibitors and modulators, β-secretase inhibitors, and amyloid-beta ... Placebo will be administered as per the schedule specified in the respective arm. Want more information about this study? Global Clinical Trials for Alzheimer’s Disease: Chapter 6. ... Presently, the drugs available for AD treatment, including cholinesterase inhibitors and an antagonist of the N-methyl-D-aspartate receptor, can only inhibit dementia symptoms for a limited . The dementia challenge is the largest health effort of the times we live in. Amyloids attempts to answer the following questions: (1) why do we develop these severe neurodegenerative diseases? (2) what histological and physiological changes are observed upon development and progression of these diseases? and (3) how ... This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic ... Territory Neurology and Research Institute, California Neuroscience Research Medical Group, Inc, Neuropsychiatric Research; Center of Southwest Florida, Miami Jewish Health Systems; Clinical Research, Alzheimer's Research and Treatment Center, Western Michigan University Homer Stryker M.D. Research Center for Clinical Studies, Inc. Norwalk, Connecticut, United States, 06851, Norwich, Connecticut, United States, 06360, Coral Gables, Florida, United States, 33134, Delray Beach, Florida, United States, 33445, Global Medical Institues, LLC; Central Miami Medical Institute, South Miami, Florida, United States, 33143, Alzheimer's Research and Treatment Center, Wellington, Florida, United States, 33414, Gainesville, Georgia, United States, 30501, Southern Illinois University, School of Medicine, Springfield, Illinois, United States, 62702, Fort Wayne, Indiana, United States, 46805, Indianapolis, Indiana, United States, 46256, Flowood, Mississippi, United States, 39232, Jackson, Mississippi, United States, 39216, Chesterfield, Missouri, United States, 63005, Mount Arlington, New Jersey, United States, 07856, Toms River, New Jersey, United States, 08755, Neurology Specialists of Monmouth County, PA, West Long Branch, New Jersey, United States, 07764, Neurological Associates of Long Island, PC, Lake Success, New York, United States, 11042, Raleigh, North Carolina, United States, 27609, Ohio State University; College of Medicine, Oregon Center for Clinical Investigations, Inc, Oregon Health and Science University, Layton Aging and Alzheimer's Disease Center, Abington, Pennsylvania, United States, 19001, Jenkintown, Pennsylvania, United States, 19046, Philadelphia, Pennsylvania, United States, 19102, Charleston, South Carolina, United States, 29425, Port Royal, South Carolina, United States, 29935, Knoxville, Tennessee, United States, 37920, Nashville, Tennessee, United States, 37203, Neurology Consultants of Dallas; Research Department, Salt Lake City, Utah, United States, 84107, Charlottesville, Virginia, United States, 22906, Bellevue, Washington, United States, 98007, Darlinghurst, New South Wales, Australia, 2010, Kogarah, New South Wales, Australia, 2217, Waratah, New South Wales, Australia, 2298, Mermaid Waters, Queensland, Australia, 4218, Woodville, South Australia, Australia, 5011, Heidelberg Repatriation Hospital; Medical and Cognitive Research Centre, Heidelberg West, Victoria, Australia, 3081, HammondCare Aged Psychiatry Clinical Trials, Australian Alzheimer's Research Foundation, Nedlands, Western Australia, Australia, 6009, Hospital Nossa Senhora das Graças; Setor de Pesquisa em Neurologia, Universidade Federal de Sao Paulo - UNIFES, Hospital das Clinicas - FMUSP_X; Neurologia, Kelowna, British Columbia, Canada, V1Y 3G8, Penticton, British Columbia, Canada, V1Y 1Z9, Powell River, British Columbia, Canada, V8A 3B6, Vancouver, British Columbia, Canada, V6Z 1Y6, The Medical Arts Health Research Group - West Vancouver, Vancouver, British Columbia, Canada, V7T 2Z3, Victoria, British Columbia, Canada, V8R 1J8, Center for Diagnosis and Research on Alzheimer's disease, Institute Universitaire de Geriatrie de Montreal, Beijing Tian Tan Hospital,Capital Medical University, Guangdong Provincial People's Hospital; Breast, Guangzhou First Municipal People's Hospital, The Second Affiliated Hospital, Zhejiang University, The First Affiliated Hospital of Anhui Medical University, The Second Affiliated Hospital to Nanchang University, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Jiangsu Province Hospital (the First Affiliated Hospital With Nanjing Medical University), Zhongda Hospital Affiliated to Southeast University, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Huashan Hospital Affiliated to Fudan University, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Tianjin Medical University General Hospital, The First Affiliated Hospital of Wenzhou Medical College, Tangdu Hospital, The Fourth Military Medical University; Neurology Department, Centro de Investigaciones y Proyectos en Neurociencias CIPNA, Hôpital Avicenne; Centre de Recherche Clinique, Hopital Pellegrin-CHU de Bordeaux; Service de Neurologie, Groupement Hospitalier Est - Hôpital Neurologique; Neurologie A (U502), CHU de la Timone - Hopital d Adultes; Service de Neurologie, Gerontopole; Centre de Recherche clinique, Ambulates Gesundheitszentrum der Charité GmbH; MVZ Neurologie Campus Benjamin Franklin, ECRC Experimental and Clinical Research Center, Charité Campus Berlin Buch, Memory Clinic, St. Josef-Hospital, Klinik für Neurologie, Universitätsklinikum Düsseldorf; Klinik für Neurologie, NeuroCentrum Odenwald; Dres. This is a definitive overview of how the ecosystem works in transferring an AD drug from its discovery in the laboratory through clinical trial testing to regulatory review and eventual marketing. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. NursePartners, Inc. clinicians are participating in the administration of gantenerumab and the placebo. • With research mentor Dr Randall Bateman, worked on the DIAN-OBS multicenter study and DIAN-TU, a multiple-arm Phase 2/3 double-blind randomized controlled multicenter clinical trial led and . This book presents contemporary views on the genetic, biochemical, and immunological determinants of this disease. This book also concerns the issue of Alzheimer's disease prevention through lifestyle and physical activity. Patients will receive placebo or gantenerumab as subcutaneous injection with optimized titration up to the target dose. Razumovsky, Russian Medical Military Academy n.a. This book is a thoughtful exploration of how dementia challenges our ideas of personal identity and of the process of self-discovery it can bring about. This clinical trial is recruiting people who have a type of disease called Alzheimer's disease. Part 1 is a multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy and safety of gantenerumab in participants with mild Alzheimer disease. Aducanumab's yearly cost is set at $56,000 annually, which was deemed far above what estimates anticipated. This volume is a collection of reports dealing with geriatrics and gerontology. The first section provides an introduction to the common medical and non-medical problems of aging. Exclusion for Open-Label Extension (OLE): To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. S.M.Kirov; Neurology Department, St. Petersburg, Russian Federation, 194044, Hospital General Universitario de Elche; Servicio de Neurología, Policlínica Guipuzkoa; Servicio de Neurología, Donosti-San Sebastián, Guipuzcoa, Spain, 20014, Hospital de Cruces; Servicio de Neurologia, Hospital Universitario 12 de Octubre; Servicio de Neurologia, Hospital Universitario Virgen Macarena; Servicio de Neurologia, Skånes Universitetssjukhus Malmö, Minneskliniken, KAROLINSKA UNI HOSPITAL, HUDDINGE; Mottagning Kognitiv Forskning, M54, Universitäres Zentrum für Altersmedizin und Rehabilitation, Istanbul University Istanbul School of Medicine; Neurology, Dokuz Eylul University Medicine Faculty; Noroloji Departmani, Ondokuz Mayis University School of Medicine; Neurology, Sussex Partnership NHS Foundation Trust; Cognitive Treatment and Research unit, Charing Cross Hospital; Dept of Neurosciences. In March 2014, Roche started a Phase 3 trial of monthly subcutaneous injections of gantenerumab in what was anticipated to be 1,000 patients with clinical diagnoses of mild AD. All participants must show evidence of beta-amyloid pathology. Deciding to Take Part in a Trial. Alzheimer disease (AD) accounts for 60-70% of dementia cases. Abstract. However, this is a clinical study whose results are uncertain. Addressed to clinicians caring for an aging population, researchers developing new therapeutics, and policymakers concerned about the impact of early diagnosis on the delivery of health care, this timely, state-of-the-art volume constitutes ... Study record managers: refer to the Data Element Definitions if submitting registration or results information. Gantenerumab is an experimental medication that is being investigated for its ability to reduce beta-amyloid plaques in the brain that are associated with Alzheimer's disease. The second edition of Neuroimmune Pharmacology bridges the disciplines of neuroscience, immunology and pharmacology from the molecular to clinical levels with particular thought made to engage new research directives and clinical modalities ... Scientific Review. 1. Further details on Roche's criteria for eligible studies are available here (https://clinicalstudydatarequest.com/Study-Sponsors/Study-Sponsors-Roche.aspx). Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03444870. Informed Consent. For general information, Learn About Clinical Studies. Several new monoclonal antibodies have been developed and are now being tested in on going Phase II and III clinical trials, such as gantenerumab and crenezumab [94, 95]. ClinicalTrials.gov Identifier: NCT03444870, Interventional Oxidative stress in the brain plays a central role in a common pathophysiology of these diseases. This book presents scientific research on the potential of antioxidant therapy in the prevention and treatment of neurodegenerative disorders. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Gantenerumab is the first and only anti-amyloid antibody being investigated for subcutaneous administration in late-stage trials for the treatment of AD. Long before the FDA approved aducanumab (Aduhelm; Biogen) for the treatment of Alzheimer disease (AD) in June 2021—the first such approval in decades—the Six antibodies have reached phase III clinical trials: bapineuzumab, solanezumab, crenezumab, gantenerumab, aducanumab and BAN2401. Roche's experimental drug gantenerumab failed to slow cognitive decline in people with a rare inherited form of Alzheimer's disease, the latest setback for companies hunting for a cure for the . Reviewed by William J. Netzer, Ph.D., Fisher Center for Alzheimer's Research Foundation at The Rockefeller University. Eligible participants who provide separate informed consent will undergo PET imaging scans using the radioligand florbetapir as a pharmacodynamic measure of changes in brain amyloid load over time. Choosing to participate in a study is an important personal decision. Clinical Trials Shots: The P-III POLARIX trial evaluates the efficacy- safety- and PK of Polivy + R-CHP vs R-CHOP in 879 patients in a ratio (1:1) with previously untreated DLBCL for 6 cycles- followed by Rituxan for 2cycles; or R-CHOP + Polivy PBO for 6 cycles- followed by 2 cycles of Rituxan. Gantenerumab was investigated and is still being investigated in several clinical trials sponsored by Hoffmann La-Roche, Chugai Pharma, and Washington University School of Medicine. Talk with your doctor and family members or friends about deciding to join a study. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease summarizes recent developments in intervention trials in neurodegenerative diseases, particularly Alzheimer’s and Parkinson’s, as well as increasing evidence for ... However, this is a clinical study whose results are uncertain. Dementia is the common denominator of . The studies have been included in the optimized design of two ongoing P-III trials- GRADUATE 1 & 2 that evaluates the effects- safety & efficacy of gantenerumab (1020mg) vs PBO in 2-000 patients with early AD across ~350 study centers in 30+ countries globally. Furthermore, aducanumab, gantenerumab, and crenezumab are all human Aβ monoclonal antibody that bind with high affinity to aggregated Aβ, and they are still under study in . This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Individual Participant Data (IPD) Sharing Statement: Qualified researchers may request access to individual patient level data through the clinical study data request platform (www.clinicalstudydatarequest.com). How does the WN41874 clinical trial work? This book offers an in-depth discussion of the latest strategies in the field of drug design and their applications in various disorders, in order to encourage readers to undertake their own projects.It also includes the contemporary ... Approved Alzheimer medication is allowed if on stable dose for 3 months prior to screening. Razumovsky, City Psychiatric Hospital #3 of Skvortsov-Stepanov, St Petersburg, Russian Federation, 197341, Russian Medical Military Academy n.a. Aducanumab targets aggregated Aβ forms. CDR-SB is seen as more sensitive than ADAS-Cog and MMSE, and is being used in aducanumab, elenbecestat, crenezumab, and gantenerumab clinical trials (which will be detailed later). In this randomized, double-blind, placebo-controlled phase III study, we investigated gantenerumab over 2 years. AN1792, clinical trial, 441-443 Angiotensin-converting enzyme (ACE), amyloid-b degradation, 395 Animal models, Alzheimer disease clinical translation concerns, 309-312 knockout mice, 307-309 transgenic mice, 303-307 APH. For further details on Roche's Global Policy on the Sharing of Clinical Information and how to request access to related clinical study documents, see here (https://www.roche.com/research_and_development/who_we_are_how_we_work/clinical_trials/our_commitment_to_data_sharing.htm). Article. Fluency in the language of the tests used at the study site. 11-10-2021. Clinical Trials Nct Page A Multiple Ascending Dose Study of R1450 in Patients With Alzheimer Disease. In 2019, five drug trials were conducted using monoclonal antibody targeting Aβ, namely aducanumab, crenezumab, gantenerumab, and solanezumab, and one trial with a combination of gantenerumab and solanezumab. RG6100 (anti-tau) is an investigational, monoclonal IgG4 antibody that binds to multiple tau species. Klein G, Delmar P, Voyle N, Rehal S, Hofmann C, Abi-Saab D, Andjelkovic M, Ristic S, Wang G, Bateman R, Kerchner GA, Baudler M, Fontoura P, Doody R. Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer's disease: a PET substudy interim analysis. Eisai Co. Ltd. Eisai and Biogen announce presentation of additional data from the phase II clinical trial of BAN2401 in early Alzheimer's disease and the 2018 Clinical Trials on Alzheimer's . The expansion of the study triggered a clinical milestone payment to MorphoSys, the details of which were not disclosed. Call 215-884-1700 or visit the Clinical Trial Center via their website, www.theclinicaltrialcenter.com. Gantenerumab is the first fully human IgG1κ monoclonal antibody designed to bind with subnanomolar affinity to a conformational epitope on β-amyloid (Aβ) fibrils. Eculizumab. Enrollment: 1000. Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number): Why Should I Register and Submit Results? We also reviewed the English-language, pre-clinical and clinical trials designed to evaluate the efficacy or/and safety of immunotherapy drugs, from 1999 through 2011. On June 7th 2021, the Food and Drug Administration (FDA) granted approval for Aduhelm (aducanumab) for the treatment of Alzheimer's disease under its accelerated approval program. See Acylpeptide hydrolase APLPs. Insurance Coverage and Clinical Trials. Amyloid precursor protein, a membrane-bound signaling molecule, is at the very heart of . Containing over 1000 references and more than 1100 equations, drawings, photographs, micrographs, and tables, Transport Processes in Pharmaceutical Systems is a must-read resource for research pharmacists, pharmaceutical scientists and ... The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to ... Gantenerumab is also being studied in the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) trial, a global clinical study evaluating multiple compounds in individuals at risk for or with fAD. For general information, Learn About Clinical Studies. Reviewed by William J. Netzer, Ph.D., Fisher Center for Alzheimer's Research Foundation at The Rockefeller University. Talk with your doctor and family members or friends about deciding to join a study. Call 215-884-1700 or visit the Clinical Trial Center via their website, www.theclinicaltrialcenter.com. Participants will then be offered to enter into an open-label extension (OLE). The GRADUATE program is currently enrolling more than 2000 patients spanning 350 study centers. Adequate seeing and hearing ability to . To date (2013), we have witnessed over 100 years of research on Alzheimer’s disease (AD). The risk or severity of adverse effects can be increased when Durvalumab is combined with Gantenerumab. NursePartners, Inc. clinicians are participating in the administration of gantenerumab and the placebo. In the SCarlet RoAD trial, we assessed the efficacy and safety of gantenerumab in prodromal Alzheimer's disease (AD). Those trials, GRADUATE 1 and 2 (NCT03444870, NCT03443973), are phase 3 trials in which patients will be exposed to the maximum target dose of gantenerumab over a 104-week treatment period. Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR. Written by contributing authors on the frontlines of the drug research and development community, this book offers a number of key benefits that include: • A comprehensive and holistic approach to the problems and potential solutions to ... Disease on the Conduct of the Gantenerumab Clinical Trials GRADUATE Trials . Participants not willing to go to the OLE will participate in a long term follow-up period for up to 50 weeks after the last gantenerumab dose. This thorough guide details clinical trials, the drugs currently available and the expectations of the doctor, family and carer Clinical candidate Mouse antibody analog Clinical stage A . We expect data from the studies in 2022. . Alzheimer’s disease is undoubtedly the major health challenge of our Century with significant social and economic consequences. School of Medicine Center for Clinical Research, Rhode Island Mood & Memory Research Institute, University of Utah, Center for Alzheimer's Care Imaging & Research, U.S Department of Health and Human Services (HHS), Talking With Your Patients About Clinical Trials, Clinical diagnosis of probable mild Alzheimer disease, based on NINCDS/ADRDA criteria, Available caregiver who has frequent contact with the participant and can provide accurate information about his or her cognitive and functional abilities, Fluency in the language of the tests used at the study site, Adequate seeing and hearing ability to perform neuropsychological testing (eyeglasses and hearing aids are permitted), If taking Alzheimer's medication, must have been on stable dose for at least 5 months prior to joining the study, Dementia due to a condition other than Alzheimer's, including but not limited to frontotemporal dementia, Parkinson disease, dementia with Lewy bodies, Huntington disease, or vascular dementia, History or presence of clinically evident vascular disease that may affect cognitive function, History or presence of stroke within the past 2 years or documented history of transient ischemic attack within the past year, History or presence of systemic autoimmune disorders potentially causing progressive neurologic disease with associated cognitive deficits, History of schizophrenia, schizoaffective disorder, or bipolar disorder, Alcohol and/or substance abuse or dependence (according to the DSM-5) within the past 2 years (nicotine use is allowed), History or presence of atrial fibrillation, Unstable or clinically significant cardiovascular disease within the past 2 years (for example, myocardial infarction, angina pectoris, or cardiac failure), Chronic kidney disease or impaired hepatic function. the aducanumab and gantenerumab clinical results, . Aducanumab, a human-derived antibody targeting amyloid-β (Aβ), is in Phase 3 clinical trials for the treatment of Alzheimer's disease. Participants will be randomized to receive either gantenerumab subcutaneously every 4 weeks or placebo subcutaneously every 4 weeks. S.M.Kirov; Neurology Department, St. Petersburg, Russian Federation, 194044, SBHI SR Region Specialized Psychiatric Hospital #2, Hospital Universitari de Bellvitge; Servicio de Neurologia, L'Hospitalet de Llobregat, Barcelona, Spain, 08907, Hospital General De Catalunya; Servicio de Neurologia, Sant Cugat del Valles, Barcelona, Spain, 8195, Hospital Universitario Marques de Valdecilla; Servicio de Neurología, UVaMID Hospital Santa Caterina;; Servicio de Neurología, Hospital San Pedro; Servicio de Neurología, HM Universitario Puerta del Sur CINAC (C.Integ.Neuroc);; Servicio de Psiquiatría, Complejo Asistencial Universitario de Salamanca; Servicio de Psiquiatría, Hospital General Universitario de Albacete; Servicio de Neurología, Hospital Universitari Quiron Dexeus;; Servicio Neurología, Hospital Vall d'Hebron; Servicio de Neurología, Hospital Clinic i Provincial; Servicio de Neurologia, Hospital de la Santa Creu i Sant Pau; Servicio de Neurologia, Hospital Universitario Reina Sofia; Servicio de Neurologia, Hospital Ramon y Cajal; Servicio de Neurologia, Hospital Ruber Internacional; Servicio de Neurología, Hospital Universitario 12 de Octubre; Servicio de Neurologia, Hospital Virgen del Rocío; Servicio de Neurología, Hospital Universitario Dr. Peset; Servicio de Neurologia.

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